Surgical Critical Care Committee Literature Reviews

The Surgical Critical Care Committee has identified the following literature reviews to help identify best-practice and appropriate standards for clinical management of pediatric surgical disease.

If you have questions, contact Samir Gadepalli.


The APSA Surgical Critical Care Committee

View the current members of this committee.


Earn MOC CME from the Literature Reviews

Continuing medical education maintenance of certification self-assessment credit is now available for the Cancer, Critical Care, Ethics, Outcomes and Trauma literature reviews.
  • ExPERT subscribers: log onto ExPERT, go to Pre-Created courses, look for "Articles" under course type and select the desired course. Remember to use Chrome or Safari.
  • Not a subscriber yet? Purchase ExPERT and start earning MOC CME*.

*Subscriptions purchased prior to October 1 expire December 31. Subscriptions purchased October 1 or later expire December 31.


Literature Reviews

Dexmedetomidine for Sedation During Noninvasive Ventilation in Pediatric Patients.
Venkatraman R, Hungerford JL, Hall MW, Moore-Clingenpeel M, Tobias JD.
Pediatr Crit Care Med. 2017 Sep;18(9):831-837.
Summary: Over the past 10 years or so the use of dexmedetomidine has become progressively more and more widespread. In many centers it is now routinely used as the first line agent for sedation in the PICU. In addition, because of its safety profile when it comes to hypotension and respiratory depression, many have begun to use Dexmedetomidine with weening protocols, post extubation, and with non-invasive ventilation. However, very little data has been collected and published in children for these uses.

This Study is a single center retrospective report collecting data on the use of Dexmedetomidine, specifically in children while receiving non-invasive ventilation. The results demonstrate a reasonable safety profile, and to some extent validates a practice that is an evolving trend in many institutions.

The American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock: Executive Summary.  
Davis AL, et al.
Pediatr Crit Care Med. 2017;  Sep;18(9):884-890.
PubMed PMID: 28723883.
Summary: Guidelines for the care of septic shock in pediatrics were developed in 2002 and updated in 2007, and have become standards throughout the country.   The American College of Critical Care Medicine has now finalized the next update and provided an executive summary of the key points of these guidelines.  The new recommendations advocate hospital specific guidelines that address three key issues: recognition of sepsis, resuscitation and stabilization, and performance.  Practical examples of potential bundles to address each of these issues are provided in the summary.

Functional Outcome After Intracranial Pressure Monitoring for Children With Severe Traumatic Brain Injury.
Bennett TD, DeWitt PE, Greene TH, Srivastava R, Riva-Cambrin J, Nance ML,  Bratton SL, Runyan DK, Dean JM, Keenan HT
JAMA Pediatr. 2017 Oct 1;171(10):965-971.
PMID: 28846763.
Summary: The widespread use of intracranial pressure monitors for severe traumatic brain injury in children has been a passionately debated topic over the past several years, with conflicting expert opinion and low likelihood of a true randomized controlled trial to settle the questions.   This study collected data from two large national databases and used sophisticated statistical analysis on cohorts of patients to look at outcome measures with and without the use of ICP monitoring.   They concluded there was no association between ICP monitor use and functional survival. 

Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition
Mehta NM, Skillman HE, Irving SY, Coss-Bu JA, Vermilyea S, Farrington EA, McKeever L, Hall AM, Goday PS, Braunschweig C.
Pediatr Crit Care Med. 2017 Jul;18(7):675-715
PMID: 28691958

Neurodevelopmental outcomes in infants undergoing general anesthesia
Nestor KA, Zeidan M, Boncore E, Richardson A, Alex G, Weiss M, Islam S.
J Pediatr Surg. 2017 Jun;52(6):895-900
PMID: 28342581 

Centrifugal pumps and hemolysis in pediatric extracorporeal membrane oxygenation (ECMO) patients: An analysis of Extracorporeal Life Support Organization (ELSO) registry data
O'Brien C, Monteagudo J, Schad C, Cheung E, Middlesworth W4
J Pediatr Surg. 2017 Jun;52(6):975-978
PMID: 28359588

Comparative Effectiveness of Nonsteroidal Anti-inflammatory Drug Treatment vs No Treatment for Patent Ductus Arteriosus in Preterm Infants
Slaughter JL, Reagan PB, Newman TB, Klebanoff MA.
JAMA Pediatr. 2017 Mar 6;171(3):e164354. doi: 10.1001/jamapediatrics.2016.4354. Epub 2017 Mar 6.
PMID: 28046188

Pulmonary Hypertension Therapy and a Systematic Review of Efficacy and Safety of PDE-5 Inhibitors
Unegbu C, Noje C, Coulson JD, Segal JB, Romer L.
Pediatrics. 2017 Mar;139(3). pii: e20161450. doi: 10.1542/peds.2016-1450.
PMID: 28235796 

Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children
Moler FW et al
N Engl J Med. 2017 Jan 26;376(4):318-329. doi: 10.1056/NEJMoa1610493. Epub 2017 Jan 24.
PMID: 28118559 

Effect of Inhaled Nitric Oxide on Outcomes in Children with Acute Lung Injury: Propensity Matched Analysis From a Linked Database
Gupta P, Richardson T, Hall M, Bertoch D, Hebbar KB, Fortenberry JD, Wetzel RC.
Crit Care Med 2016 Oct; 44(10): 1901-9.
PMID: 27163193 

Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults
Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL; AWARE Investigators.
N Engl J Med. 2017 Jan;376(1):11-20.
PMID: 27959707 

New Medical and Surgical Insights into Neonatal Necrotizing Enterocolitis: A Review
Frost BL, Modi BP, Jaksic T, Caplan MS.
JAMA Pediatr 2017 Jan; 171(1): 83-88.
PMID: 27893069

Impact of Weight Extremes on Clinical Outcomes in Pediatric Acute Respiratory Distress Syndrome
Ward SL, Gildengorin V, Valentine SL, Sapru A, Curley MA, Thomas N, Willson DF, Flori HR.
Crit Care Med. 2016 Nov;44(11):2052-2059.
PMID: 27355525

Prediction of Catheter-Associated Thrombosis in Critically Ill Children
Marquez A, Shabanova V, Faustino EV; Northeast Pediatric Critical Care Research Consortium.
Pediatr Crit Care Med. 2016 Sep 22.
PMID: 27662566

Persistent Challenges in Pediatric Pulmonary Hypertension
Hopper RK, Abman SH, Ivy DD.
chest 2016 Jul;150(1):226-36. doi: 10.1016/j.chest.2016.01.007. Epub 2016 Jan 22.
PMID: 26836930  

High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial
Wu YW, Mathur AM, Chang T, McKinstry RC, Mulkey SB, Mayock DE, Van Meurs KP, Rogers EE, Gonzalez FF, Comstock BA, Juul SE, Msall ME, Bonifacio SL, Glass HC, Massaro AN, Dong L, Tan KW, Heagerty PJ, Ballard RA.
Pediatrics. 2016 Jun;137(6). pii: e20160191. doi: 10.1542/peds.2016-0191. Epub 2016 May 2.
PMID: 27244862

Evaluation of the "Early" Use of Albumin in Children with Extensive Burns: A Randomized Controlled Trial
Pediatr Crit Care Med. 2016 Jun;17(6):e280-6. doi: 10.1097/PCC.0000000000000728.
Müller Dittrich MH, Brunow de Carvalho W, Lopes Lavado E.
PMID: 27077832

Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension
Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman JR, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman SH.
J Pediatr. 2016 Mar;170:312-4. doi: 10.1016/j.jpeds.2015.11.050. Epub 2015 Dec 15.
PubMed PMID: 26703869.

New Modes in Non-invasive Ventilation
Rabec C, Emeriaud G, Amadeo A, Fauroux B, Georges M.
Paediatr Respir Rev. 2016 Mar;18:73-84. doi:10.1016/j.prrv.2015.10.004. Epub 2015 Oct 24. Review.
PubMed PMID: 26688194.

Obesity and Mortality Risk in Critically Ill Children
Ross PA, Newth CJ, Leung D, Wetzel RC, Khemani RG.
Pediatrics. 2016 Mar;137(3):1-8. doi:10.1542/peds.2015-2035. Epub 2016 Feb 16.
PubMed PMID: 26908670.

Mortality Among Injured Children Treated at Different Trauma Center Types
Sathya C, Alali AS, Wales PW, Scales DC, Karanicolas PJ, Burd RS, Nance ML, Xiong W, Nathens AB.
JAMA Surg. 2015 Sep;150(9):874-81. doi: 10.1001/jamasurg.2015.1121.
PMID: 26106848
Similar articles

Maintenance Intravenous Fluids in Acutely Ill Patients
Moritz ML, Ayus JC.
N Engl J Med. 2016 Jan 21;374(3):290-1. doi: 10.1056/NEJMc1513887. No abstract available.
PMID: 26789888

Ventilatory support in children with pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference
Rimensberger PC, Cheifetz IM; Pediatric Acute Lung Injury Consensus Conference Group.
Pediatr Crit Care Med. 2015 Jun;16(5 Suppl 1):S51-60. doi: 10.1097/PCC.0000000000000433.
PMID: 26035364
Similar articles   

Mortality Among Injured Children Treated at Different Trauma Center Types
Sathya C, Alali AS, Wales PW, Scales DC, Karanicolas PJ, Burd RS, Nance ML, Xiong W, Nathens AB.
JAMA Surg. 2015 Sep;150(9):874-81. doi: 10.1001/jamasurg.2015.1121.
PMID: 26106848
Similar articles